chromatographic separation of some antiemetics on silica gel-surfactant impregnated thin-layer plates

A thin layer chromatographic (TLC) separation of five antiemetic agents on silica gel-surfactant impregnated plates using a mixture of ethanol-water-acetic acid (40:50:10) as developing system was studied. The visualization of the spots was done by exposure of the plates to iodine vapour. Of the two surfactants employed (polysorbate-80 and sodium lauryl sulfate) at various concentrations, sodium lauryl sulfate at 1.25% w/v concentration level exhibited the best separation ability.

 C.J Mbah, S.U Uzodinma